Introducing Klio: AI Prescription Agent for Clinicians

Klio is built for clinicians who want prescription writing to move at the speed of care. Type a single clinical instruction and Klio drafts the prescription, checks interactions, and prepares the fax in seconds.

Prescription writing in clinical practice remains one of the most fragmented tasks a physician performs daily. It typically involves reviewing patient notes, searching a drug reference, verifying dosages, cross-checking interactions, printing or faxing the final document, and reconciling RAMQ codes for reimbursement. Each of those steps lives in a different system. The cognitive overhead is real, and the risk of error grows with every context switch. Klio was built to eliminate that fragmentation by collapsing the entire prescription workflow into a single conversational agent.

What Klio does

Klio is an AI prescription agent that transforms a single clinical instruction into a complete, verified prescription ready for delivery. It is not a general-purpose chatbot or a note generator. It is purpose-built for the act of prescribing: drug selection, dosage structuring, interaction safety, and transmission to the pharmacy.

• Creates structured prescriptions from voice or text instructions
• Fuzzy-matches drug names against a database of over 250,000 entries, resolving brand names to generics automatically
• Maps RAMQ drug codes for reimbursement eligibility in Quebec
• Checks drug interactions in real time across 250,000+ drug pairs before signoff
• Supports heparin bridge and surgical hold workflows with structured protocols
• Prepares one-click fax delivery for fast outpatient execution
• Operates in both English and French with full bilingual support

How Klio works: step by step

The entire Klio workflow is designed to move from clinical intent to signed prescription in under 30 seconds. Here is what happens when a clinician types or dictates an instruction like "start apixaban 5 mg BID and hold ASA for 7 days pre-op":

1. Clinical instruction parsing. Klio interprets the natural language instruction and extracts drug names, dosages, routes, frequencies, durations, and any conditional logic (holds, bridges, tapers).
2. Drug resolution. Each drug name is fuzzy-matched against a comprehensive database of over 250,000 entries. Brand names are resolved to their generic equivalents. RAMQ drug identification numbers (DINs) are mapped automatically for Quebec prescribers.
3. Interaction screening. Klio runs a pairwise interaction check across the patient's current medications and the new prescription. The system evaluates over 250,000 known drug-drug interaction pairs and flags results by severity: low, moderate, or high.
4. Prescription structuring. The agent assembles a formatted prescription with drug name, strength, dosage form, route, frequency, quantity, and refill count. For perioperative workflows, it generates separate hold and bridge documents.
5. Clinician review and signoff. The complete prescription is presented for review. The clinician can modify any field, override interaction warnings with clinical justification, or approve as-is.
6. One-click fax delivery. Once approved, the prescription is sent to the designated pharmacy via fax with a single click. No printing, no scanning, no phone calls.

Real-time drug interaction checking

Drug interactions are one of the leading causes of preventable adverse events in outpatient care. Traditional interaction checking happens too late in the workflow, often after a prescription has already been printed or sent. Klio moves the safety check upstream: interactions are evaluated the moment the prescription is drafted, before the clinician signs off.

The interaction engine covers over 250,000 drug-drug pairs with severity grading. When a high-severity interaction is detected, such as the well-known bleeding risk between aspirin and apixaban, Klio presents a clear alert with the specific risk category (e.g., bleeding, QT prolongation, nephrotoxicity). The clinician can then choose to modify the prescription, override the alert with documented justification, or cancel the order entirely. Every interaction check runs in under one second, so it never slows down the prescribing workflow.

Heparin bridge and surgical hold protocols

Perioperative anticoagulation management is one of the highest-stakes prescription workflows in clinical medicine. Bridging a patient from an oral anticoagulant to heparin before surgery, and then back again postoperatively, requires precise timing, correct dosing, and clear communication between the prescriber, the surgeon, and the pharmacy. Errors in bridge protocols are associated with both thromboembolic and hemorrhagic complications.

Klio supports this workflow natively. When a clinician instructs Klio to set up a heparin bridge, the agent generates a structured perioperative bridge protocol that includes the pre-operative hold date, the bridging anticoagulant with dosing schedule, the target surgery date, and the postoperative resumption plan. Each component is presented as a separate, reviewable section. The clinician reviews the complete protocol, makes any adjustments, and sends the full set of documents to the pharmacy in a single fax.

Built for Quebec prescribing

Klio was designed from the ground up for the Quebec healthcare environment. Prescribing in Quebec has specific requirements that generic prescription tools rarely address: RAMQ drug coverage codes, bilingual documentation obligations, and fax-based pharmacy communication that remains the standard in most community pharmacies across the province.

• RAMQ drug code mapping. Klio automatically resolves Drug Identification Numbers (DINs) and maps them to RAMQ formulary codes, so clinicians know at prescribing time whether a medication is covered under the public drug plan.
• Bilingual workflows. The entire interface operates in both English and French. Clinicians can write instructions in either language and switch at any time. Prescription documents are generated in the language required by the receiving pharmacy.
• Brand-to-generic resolution. Klio resolves brand names to their generic equivalents, which is particularly important in Quebec where pharmacists routinely substitute generics under RAMQ rules.
• Fax delivery infrastructure. One-click fax transmission is built directly into the workflow. No need for external fax services, printer-scanner loops, or manual phone calls to the pharmacy.

Intelligent drug name resolution

One of the most time-consuming aspects of prescription writing is getting the drug name exactly right. Clinicians think in terms of brand names, abbreviations, and shorthand. Pharmacy systems expect precise generic names, DINs, and formulary codes. This translation step is where errors creep in, especially under time pressure.

Klio uses fuzzy matching against a comprehensive drug database of over 250,000 entries. Type "plavix 75" and Klio resolves it to clopidogrel bisulfate 75 mg with the correct DIN and RAMQ code. Type "lasix 40 po daily" and it maps to furosemide 40 mg oral once daily. The matching algorithm handles misspellings, partial names, and common clinical abbreviations, so the clinician never needs to leave the prescribing interface to look up a drug reference.

Security and compliance

Prescription data is among the most sensitive categories of personal health information. Klio is built with the same security posture as the FrontRx clinical documentation platform. All data is encrypted in transit and at rest. The platform is compliant with PHIPA (Ontario), PIPEDA (federal), and aligns with HIPAA standards for organizations operating across the border. For Quebec-based practices, Klio's architecture is designed to meet the requirements of Law 25 (Quebec's privacy legislation) regarding the handling of personal information.

No prescription data is used for model training. Clinician instructions and patient medication data are processed in real time and are not retained beyond the active session unless explicitly saved by the clinician. Audit logs are maintained for all prescription actions, supporting institutional compliance requirements.

Prescribing with Klio vs. without Klio

Why we built Klio

FrontRx was founded by interventional cardiologists at the Montreal Heart Institute who write dozens of prescriptions every day. We know firsthand that the prescribing workflow in Canadian practice is broken: too many systems, too many manual steps, and too many opportunities for error. We built Klio because we needed it ourselves.

Prescription work is still fragmented across note review, medication lookup, interaction checking, and faxing. Klio compresses that sequence into one agent workflow so clinicians can move faster with less context switching. The result is not just speed. It is fewer errors, better interaction coverage, and a prescribing experience that actually respects the pace of clinical care.

Who Klio is for

Klio is designed for any prescribing clinician in Quebec and across Canada. It is particularly well-suited for physicians in high-volume outpatient practice, specialists managing complex medication regimens (cardiology, internal medicine, geriatrics), and clinicians who regularly handle perioperative anticoagulation. Family physicians who want faster, safer outpatient prescription workflows will also find immediate value.

Getting started

Klio is currently available in beta for clinicians on the FrontRx platform. It runs entirely in the browser at klio.frontrx.com, with no software to install. Sign up for access, type your first instruction, and experience prescription writing at the speed of care.

Written by Robert Avram, MD, MSc, FRCPC, Interventional Cardiologist at the Montreal Heart Institute and co-founder of FrontRx.